Comprehensive targeted and non-targeted lipidomics analyses in failing and non-failing heart
نویسندگان
چکیده
منابع مشابه
Targeted uptake-1 carrier to rescue the failing heart.
Heart failure is characterized by sympathetic nervous system activation with consequent increase in cardiac and systemic norepinephrine (NE) release. Sympathetic hyperactivity preferentially targets the heart during early stages of failure and subsequently involves other organs. A landmark study published in 1984 by Cohn et al showed that plasma NE concentration in venous blood sampled at rest ...
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UNLABELLED The failing human heart is characterized by changes in the expression and function of proteins involved in intracellular Ca2+ cycling, resulting in altered Ca2+ transients and impaired contractile properties of cardiac muscle. The role of the cardiac annexins in this process remains unclear. Annexins may play a role in the regulation of Ca2+ pumps and exchangers on the sarcolemma, an...
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although there are studies on pragmatic assessment, to date, literature has been almost silent about native and non-native english raters’ criteria for the assessment of efl learners’ pragmatic performance. focusing on this topic, this study pursued four purposes. the first one was to find criteria for rating the speech acts of apology and refusal in l2 by native and non-native english teachers...
15 صفحه اولGender Differences in Electrophysiological Gene Expression in Failing and Non-Failing Human Hearts
The increasing availability of human cardiac tissues for study are critically important in increasing our understanding of the impact of gender, age, and other parameters, such as medications and cardiac disease, on arrhythmia susceptibility. In this study, we aimed to compare the mRNA expression of 89 ion channel subunits, calcium handling proteins, and transcription factors important in cardi...
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OBJECTIVES This study investigated the hypothesis whether S100A1 gene therapy can improve pathological key features in human failing ventricular cardiomyocytes (HFCMs). BACKGROUND Depletion of the Ca²⁺-sensor protein S100A1 drives deterioration of cardiac performance toward heart failure (HF) in experimental animal models. Targeted repair of this molecular defect by cardiac-specific S100A1 ge...
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ژورنال
عنوان ژورنال: Analytical and Bioanalytical Chemistry
سال: 2018
ISSN: 1618-2642,1618-2650
DOI: 10.1007/s00216-018-0863-7